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  • When is quadruple test done

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    Quadruple screen test

    The quadruple screen test is a blood test done during pregnancy to determine whether the baby is at risk for certain birth defects.

    This test is most often done between the 15th and 22nd weeks of the pregnancy.

    It is most accurate between the 16th and 18th weeks.

    A blood sample is taken from the pregnant woman and sent to the lab for testing.

    The test measures levels of 4 pregnancy hormones:

    • Alpha-fetoprotein (AFP), a protein produced by the baby
    • Human chorionic gonadotropin (hCG), a hormone produced in the placenta
    • Unconjugated estriol (uE3), a form of the hormone estrogen produced in the fetus and the placenta
    • Inhibin A, a hormone released by the placenta

    If the test does not measure levels of inhibin A, it is called the triple screen test.

    To determine the chance of your baby having a birth defect, the test also factors in:

    • Your age
    • Your ethnic background
    • Your weight
    • Your baby's gestational age (measured in weeks from the day of your last period to the current date)

    No special steps are needed to prepare for the test.

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