Cla benefits and dangers
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Cla dosage and timing!
Cla for women
Pros and cons of CLA consumption: an insight from clinical evidences
Conjugated linoleic acids (CLAs) encompass a group of positional and geometric isomers of octadecadienoic acids (18:2) – naturally occurring polyunsaturated fatty acids or PUFA- synthesized in the rumen of cattle, deer, sheep and goat by microbial biotransformation of forage-derived fatty acids (FAs) such as oleic acid (OA), linoleic acid (LA) and α-linolenic acid (ALA) ultimately into saturated stearic acid (SA) [1, 2].
Although CLA is formed as an intermediate during ruminal biohydrogenation of OA, LA and ALA, its primary source in vivo is endogenous (de novo) synthesis by the activity of Δ9-desaturase from the monounsaturated FA (MUFA), the vaccenic acid (trans-11,18:1; VA), another intermediate in ruminal biohydrogenation [3].
It is also synthesized endogenously in humans from dietary VA by the activity of Δ9-desaturase [4, 5] (Figure 1). The Δ9-desaturase (also referred to as stearoyl-CoA desaturase; EC 1.14.99.5) catalyzes the addition of a cis-9 double bond on the VA, and was shown to be p
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